If I can get away with it, with the Small chord size, I try to use simple chords like F- or G7 instead of F-6 or G7b9.
If they clash, at least the player will play them correctly.
You can use 8 spaces for a measure - the player does not respond to the eighth notes after the main beats, but will be clearer to read and they can be all normal size. Just insert a space after each beat and the barlines will move along (this is assuming 4/4.)