We jazz players have 2-5-1's all over the place.
It's often easier to think of a 2-5-1 (or similar changes) as being in a temporary new key.

Case in point: Blue Bossa:
Measures 5 through 8 are a standard 2-5-1 in the key of C minor.
Measures 9 through 12 are shown in number font as b3-6-b2.
It's much easier, however, to think of measures 9 through 12 as a 2-5-1 in the temporary new key of Db major.

There are countless other songs with temporary key changes.
Can iRealPro incorporate this?